Latrunculin A; Latrunculia magnifica

Biochem/physiol Actions

Primary TargetG-actin

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

Kd = 200 nM in formation of a 1:1 complex with monomeric G-actin

General description

A cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (K_d = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos. A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428026 in DMSO is also available.

A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (K_d = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ayscough, K.R., et al. 1997. J. Cell Biol. 137, 399.Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.Coue, M., et al. 1987. FEBS Lett. 213, 316.Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.Spector, I., et al. 1983. Science 219, 493.

Packaging

Packaged under inert gas

100 µg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)